系统(IUPAC)命名名称 | |
---|---|
(8R,9S,13S,14S,17R)-17-ethynyl-17-hydroxy-13-methyl-1,2,4,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-3-one | |
临床数据 | |
商品名 | Enovid (with mestranol), others |
给药途径 | 口服给药 |
药代动力学数据 | |
蛋白结合度 | Noretynodrel:至albumin and not至SHBG or CBG[1] |
代谢 | Liver, intestines (hydroxylation, isomerization, conjugation)[1][2] |
代谢产物 | • 3α-Hydroxynoretynodrel[3] • 3β-Hydroxynoretynodrel[3] • Norethisterone[1][2][3] • Ethinylestradiol[2][4]• Conjugates[2] |
生物半衰期 | Very short (< 30 minutes)[5] |
排泄 | Breast milk: 1%[6] |
识别信息 | |
CAS注册号 | 68-23-5 |
ATC代码 | G03FA09 |
PubChem | CID 6231 |
DrugBank | DB09371 |
ChemSpider | 5995 |
UNII | 88181ACA0M |
KEGG | D05207 |
ChEBI | CHEBI:34895 |
ChEMBL | CHEMBL1387 |
其他名称 | Norethynodrel; Noretinodrel Norethinodrel; NYD; SC-4642; NSC-15432; 5(10)-Norethisterone; 17α-Ethinyl-19-nor-5(10)-testosterone; 17α-Ethynyl-δ5(10)-19-nortestosterone; 17α-Ethynylestr-5(10)-en-17β-ol-3-one; 19-Nor-17α-pregn-5(10)-en-20-yn-17β-ol-3-one |
化学信息 | |
化学式 | C20H26O2 |
摩尔质量 | 298.419 g/mol |
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异炔诺酮(英语:Noretynodrel 或 英语:norethynodrel,商品名:Enovid等)是一种黄体制剂药物,过去被用于口服避孕药以及治疗一些妇科疾病,但现在已不再使用[2][6][7][8]。异炔诺酮和炔诺酮的不同之处在于双键位于5(10)号位而非4(5)号位。
参考文献
- ↑ 1.0 1.1 1.2 Kuhl H. Pharmacokinetics of oestrogens and progestogens. Maturitas. September 1990, 12 (3): 171–97. PMID 2170822. doi:10.1016/0378-5122(90)90003-O.
- ↑ 2.0 2.1 2.2 2.3 2.4 Kuhl H. Pharmacology of estrogens and progestogens: influence of different routes of administration (PDF). Climacteric. 2005,. 8 Suppl 1: 3–63 [2019-06-30]. PMID 16112947. doi:10.1080/13697130500148875.
- ↑ 3.0 3.1 3.2 Jin Y, Duan L, Chen M, Penning TM, Kloosterboer HJ. Metabolism of the synthetic progestogen norethynodrel by human ketosteroid reductases of the aldo-keto reductase superfamily. J. Steroid Biochem. Mol. Biol. 2012, 129 (3–5): 139–44. PMC 3303946 . PMID 22210085. doi:10.1016/j.jsbmb.2011.12.002.
- ↑ Kuhl H. Pharmacology of Progestogens (PDF). J Reproduktionsmed Endokrinol. 2011, 8 (1): 157–177 [2019-07-10].
- ↑ Hammerstein J. Prodrugs: advantage or disadvantage?. Am. J. Obstet. Gynecol. 1990, 163 (6 Pt 2): 2198–203. PMID 2256526.
- ↑ 6.0 6.1 Sweetman, Sean C. (编). Sex hormones and their modulators. Martindale: The Complete Drug Reference 36th. London: Pharmaceutical Press. 2009: 2120–2121. ISBN 978-0-85369-840-1.
- ↑ Jucker. Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Birkhäuser. 21 December 2013: 85–88. ISBN 978-3-0348-7065-8.
- ↑ Lara Marks. Sexual Chemistry: A History of the Contraceptive Pill. Yale University Press. 2010: 74–75. ISBN 978-0-300-16791-7.